Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5

Frank L. Graham, W. C. Russell, James R. Smiley, +1

Journal of General Virology

Viral ReplicationSds PageRestriction FragmentsNatural SciencesMolecular Biology +9

Mdm2 promotes the rapid degradation of p53

Ygal Haupt, Ruth Maya, Anat Kazaz, +1

Nature

Tumor BiologyMedicineRapid DegradationProtein DegradationTumor Suppressor +4

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

Reiko Honda, Hirofumi Tanaka, Hideyo Yasuda

FEBS Letters

A Small Ubiquitin-Related Polypeptide Involved in Targeting RanGAP1 to Nuclear Pore Complex Protein RanBP2

Rohit Mahajan, Christian Delphin, Tinglu Guan, +2

Cell

Protein FunctionSignal TransductionMedicineNatural SciencesMolecular Biology +7

A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex.

Michael J. Matunis, Elias Coutavas, Gerd A. Blobel

The Journal of Cell Biology

Molecular BiologyNuclear Pore ComplexNovel Ubiquitin-like ModificationCytoskeletonRan-gtpase-activating Protein Rangap1 +14

SUMO-1 Modification of IκBα Inhibits NF-κB Activation

Joana Desterro, Manuel S. Rodríguez, Ronald T. Hay

Molecular Cell

InflammationCytokineTranscriptional RegulationSignal TransductionSignaling Pathway +8

The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites

Sheau-Yann Shieh, Jin-Woo Ahn, Katsuyuki Tamai, +2

Genes & Development

Kinase-defective Hchk1Cell DeathMolecular BiologyCell CycleTumor Biology +19

Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

M Debbas, Eileen White

Genes & Development

Cancer ResearchSystems BiologyCell RegulationAdenovirus E1aApoptosis +11

Chk2/hCds1 functions as a DNA damage checkpoint in G₁by stabilizing p53

Nabil Chehab, Asra Malikzay, Michael Appel, +1

Genes & Development

ApoptosisMolecular BiologyCell DeathCell CycleDominant-negative P53 Mutant +18

p53 Sites Acetylated In Vitro by PCAF and p300 Are Acetylated In Vivo in Response to DNA Damage

Lin Liu, Daniel M. Scolnick, Raymond C. Trievel, +4

Molecular and Cellular Biology

Lysine Residue DistinctDna DamageApoptosisCell DeathMolecular Biology +16