Anxiolytic Effects in Mice of a Dual Blocker of Fatty Acid Amide Hydrolase and Transient Receptor Potential Vanilloid Type-1 Channels

Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor

William A. Devane, L Hanŭs, Aviva Breuer et al. · Science · 1992 · 5.6K citations

Brain Constituent, Neurotransmitter, Cannabinoid Pharmacology +17

Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors

Raphael Mechoulam, Shimon Ben‐Shabat, L Hanŭs et al. · Biochemical Pharmacology · 1995 · 2.9K citations

Cannabis Use, Gastrointestinal Peptide Hormone, Functional Selectivity +6

2-Arachidonoylgylcerol: A Possible Endogenous Cannabinoid Receptor Ligand in Brain

Takayuki Sugiura, Shigeru Kondo, Akihiro Sukagawa et al. · Biochemical and Biophysical Research Communications · 1995 · 2.2K citations

Cannabis Use, Molecular Pharmacology, Functional Selectivity +9

Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide

Peter M. Zygmunt, Jesper Petersson, David A. Andersson et al. · Nature · 1999 · 2.1K citations

Neurophysiology, Neuroanatomy, Synaptic Transmission +12

The endogenous cannabinoid system controls extinction of aversive memories

Giovanni Marsicano, Carsten T. Wotjak, Shahnaz Christina Azad et al. · Nature · 2002 · 1.7K citations

Cannabis Use, Cognitive Science, Addiction +7