Concepedia

Evaluation of the safety and pharmacokinetics of the multi‐targeted receptor tyrosine kinase inhibitor sunitinib during embryo–fetal development in rats and rabbits

Shem Patyna, Joshua Haznedar, David L. Morris, Karen J Freshwater, Geoffrey W. Peng, Juthamas Sukbuntherng, G. Chmielewski, Diane Matsumoto

Birth Defects Research Part B Developmental and Reproductive Toxicology · 2009 · 44 citations · 12 references

DOI

Abstract

Similar effects have been reported with the prototype monoclonal antibody bevacizumab. As is typically observed for potent inhibitors of RTKs involved in angiogenesis, sunitinib was associated with embryo-fetal developmental toxicity in rats and rabbits at clinically relevant dose levels.

References

12

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

Napoleone Ferrara, Karen Carver-Moore, Helen Chen et al. · Nature · 1996 · 3.6K citations · Full text

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In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship.

Dirk B. Mendel, Alexander Laird, Xiaohua Xin et al. · PubMed · 2003 · 2K citations

, , +18

SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo

Anne-Marie O'Farrell, Tinya J. Abrams, Helene A. Yuen et al. · Blood · 2003 · 856 citations · Full text

SU11248 inhibits KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer.

Tinya J. Abrams, Leslie B. Lee, Lesley Murray et al. · PubMed · 2003 · 639 citations

, , +18

Vascular endothelial growth factor and the regulation of angiogenesis.

Napoleone Ferrara · PubMed · 2000 · 531 citations

, , +16