Adenoviral overproduction of interleukin-1 receptor antagonist increases beta cell replication and mass in syngeneically transplanted islets, and improves metabolic outcome

Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets

Kathrin Maedler, Frédéric Ris, José Oberholzer et al. · Journal of Clinical Investigation · 2002 · 992 citations · Full text

Life Sciences, Cell Biology, Endocrinology +17

Clinical Outcomes and Insulin Secretion After Islet Transplantation With the Edmonton Protocol

Edmond A. Ryan, Jonathan R. T. Lakey, Ray V. Rajotte et al. · Diabetes · 2001 · 872 citations · Full text

Medicine, Endocrinology, Surgery +17

Interleukin-1 (IL-1) receptor antagonist binds to the 80-kDa IL-1 receptor but does not initiate IL-1 signal transduction

David J. Dripps, Barbara J. Brandhuber, Richard Thompson et al. · Journal of Biological Chemistry · 1991 · 454 citations · Full text

Life Sciences, Immunology, Molecular Biology +10

Vulnerability of Islets in the Immediate Posttransplantation Period: Dynamic Changes in Structure and Function

Alberto M. Davalli, Luisa Scaglia, David Zangen et al. · Diabetes · 1996 · 451 citations

Medicine, Endocrinology, Physiology +16

Compensatory Growth of Pancreatic β-Cells in Adult Rats After Short-Term Glucose Infusion

Susan Bonner‐Weir, D.J. Deery, J.L. Leahy et al. · Diabetes · 1989 · 448 citations

Life Sciences, Endocrinology, Physiology +16