Soluble oligomers of amyloid-β peptide induce neuronal apoptosis by activating a cPLA2-dependent sphingomyelinase-ceramide pathway

Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo

Dominic M. Walsh, Igor Klyubin, Julia V. Fadeeva et al. · Nature · 2002 · 4.3K citations

Life Sciences, Neurobiology, Neuroscience +14

Common Structure of Soluble Amyloid Oligomers Implies Common Mechanism of Pathogenesis

Rakez Kayed, Elizabeth Head, Jennifer L. Thompson et al. · Science · 2003 · 4.1K citations

Life Sciences, Biochemistry, Neuroscience +17

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

Dora Games, David S. Adams, Ree Alessandrini et al. · Nature · 1995 · 2.5K citations

Life Sciences, Neurology, Neuroscience +16

Soluble pool of A? amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

Catriona McLean, Robert A. Cherny, Fiona Fraser et al. · Annals of Neurology · 1999 · 1.8K citations

Life Sciences, Neurobiology, Neuroscience +17

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis

Marcel Verheij, Ron Bose, Xin Lin et al. · Nature · 1996 · 1.8K citations

Life Sciences, Cell Biology, Molecular Biology +14