Different approaches for the detection of thrombin by an electrochemical aptamer-based assay coupled to magnetic beads

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In vitro selection of RNA molecules that bind specific ligands

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Selection of single-stranded DNA molecules that bind and inhibit human thrombin

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Thrombin-binding DNA aptamer forms a unimolecular quadruplex structure in solution.

Román F. Macaya, Peter Schultze, F. W. Smith et al. · Proceedings of the National Academy of Sciences · 1993 · 870 citations · Full text

Oligonucleotide inhibitors of human thrombin that bind distinct epitopes

Diane M. Tasset, Mark F. Kubik, Walter W. Steiner · Journal of Molecular Biology · 1997 · 830 citations

Thrombopoiesis, Thrombosis, Hematology +6