The cellular prion protein (PrP) selectively binds to Bcl-2 in the yeast two-hybrid system

A novel genetic system to detect protein–protein interactions

Stanley Fields, Ok-kyu Song · Nature · 1989 · 6.1K citations

Interactomics, Natural Sciences, Protein Analysis +7

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

Zoltán N. Oltval, Curt Milliman, Stanley J. Korsmeyer · Cell · 1993 · 6K citations

Bcl-2 Heterodimerizes, Cell Regulation, Apoptosis +6

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

David M. Hockenbery, Gabriel Núñez, Curt Milliman et al. · Nature · 1990 · 3.8K citations

Mitophagy, Signal Transduction, Mitochondrial Function +8

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

Lawrence Boise, Maribel González‐García, C E Postema et al. · Cell · 1993 · 3.1K citations · Full text

Hematological Malignancy, Cell Regulation, Dominant Regulator +10

Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein

Hansruedi Büeler, Marek Fischer, Yolande Lang et al. · Nature · 1992 · 1.6K citations · Full text

Neuroregeneration, Developmental Biology, Normal Development +10