Publication | Closed Access
Toward a Novel Metal-Based Chemotherapy against Tropical Diseases. 3. Synthesis and Antimalarial Activity <i>in Vitro</i> and <i>in Vivo</i> of the New Gold−Chloroquine Complex [Au(PPh<sub>3</sub>)(CQ)]PF<sub>6</sub>
139
Citations
16
References
1997
Year
Antiparasitic AgentCq DiphosphateMalariaMolecular BiologyPlasmodium FalciparumPharmaceutical ChemistryDrug ResistanceMedicinal ChemistryChloroquine-resistant StrainsBioorganometallic ChemistryAnti-cancer AgentInorganic ChemistryBiochemistryPharmacologyNovel Metal-based ChemotherapyNatural SciencesTropical DiseasesMedicineDrug Discovery
Reaction of AuPPh3Cl with chloroquine (CQ) and KPF6 leads to the new complex [Au(PPh3)(CQ)]PF6 (1) which was found to be considerably more active than CQ diphosphate and other previously reported metal−CQ complexes against two chloroquine-resistant strains of Plasmodium falciparum in vitro and also active against Plasmodium berghei in vitro and in vivo.
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