Journal of Immunology Research · 2014 · 46 citations · 23 references
MedicineCancer BiologyOncologyApoptosisCarcinogenesisGastrointestinal OncologyApoptosis In CancerBcl-2 Family ProteinsCancer BiomarkersGastric CancerGastric DiseasesBcl-2 Protein ExpressionBid-mediated SignalingClinicopathological CorrelationHelicobacter Pylori InfectionHelicobacter Pylori PathogenesisHelicobacter Pylori-associated Gastric CarcinogenesisHelicobacter-associated Gastric Carcinogenesis
BACKGROUND: Bcl-2 and BID play a major role in the process of apoptosis and their dysfunction underlies carcinogenesis. The study objective was to assess the expression of Bcl-2 and BID in gastric cancer cells in correlation with chosen clinicopathological parameters, presence of Helicobacter pylori infection, and patients' survival. MATERIALS AND METHODS: The study involved 88 patients operated on for gastric cancer. The expressions of Bcl-2 and BID were determined immunohistochemically. RESULTS: Positive Bcl-2 expression was found in 55.7% and, BID in 53.6% of patients. The Bcl-2 expression correlated with stage pT3 and T4 gastric cancer (P < 0.05), with the intestinal type according to Lauren (P < 0.001), ulcerated type according to Bormann's classification (P < 0.01), and with local lymph node metastases (P < 0.05). CONCLUSION: The Bcl-2 protein plays a key role in the process of gastric cancer formation and is associated with the growth of definite types of gastric cancer.
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Cyrus R. Mehta, Nitin R. Patel · ACM Transactions on Mathematical Software · 1986 · 206 citations · Full text
Expression of Bcl-2 Family Member Bid in Normal and Malignant Tissues
Maryla Krajewska, Juan M. Zapata, Ivo Meinhold‐Heerlein et al. · Neoplasia · 2002 · 93 citations · Full text