Urinary exosome miRNome analysis and its applications to salt sensitivity of blood pressure

Abstract

OBJECTIVES: To investigate microRNAs (miRNAs) in urinary exosomes and their association with an individual's blood pressure response to dietary salt intake. DESIGN AND METHODS: Human urinary exosomal miRNome was examined by microarray. RESULTS: Of 1898 probes tested, 194 miRNAs were found in all subjects tested. 45 miRNAs had significant associations with salt sensitivity or inverse salt sensitivity. CONCLUSION: The expression of 45 urinary exosomal miRNAs associates with an individual's blood pressure response to sodium.