A [polycation:heparin] complex releases growth factors with enhanced bioactivity

Endothelial cell-derived heparan sulfate binds basic fibroblast growth factor and protects it from proteolytic degradation.

Olli Saksela, David Moscatelli, Andreas Sommer et al. · The Journal of Cell Biology · 1988 · 806 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

The Degradation of Human Endothelial Cell-derived Perlecan and Release of Bound Basic Fibroblast Growth Factor by Stromelysin, Collagenase, Plasmin, and Heparanases

John M. Whitelock, Alan D. Murdoch, Renato V. Iozzo et al. · Journal of Biological Chemistry · 1996 · 589 citations · Full text

Medicine, Cell Biology, Pathology +15

Nerve growth factor-induced neurite outgrowth in PC12 cells involves the coordinate induction of microtubule assembly and assembly-promoting factors.

David G. Drubin, Stuart C. Feinstein, Eric M. Shooter et al. · The Journal of Cell Biology · 1985 · 515 citations · Full text

Life Sciences, Neurobiology, Neuroscience +12

Controlled release of nerve growth factor from a heparin-containing fibrin-based cell ingrowth matrix

Shelly E. Sakiyama‐Elbert, Jeffrey A. Hubbell · Journal of Controlled Release · 2000 · 424 citations · Full text

Engineering, Bioengineering, Biomedical Engineering +16

Growth factor gradients via microsphere delivery in biopolymer scaffolds for osteochondral tissue engineering

Xiaoqin Wang, Esther Wenk, Xiaohui Zhang et al. · Journal of Controlled Release · 2008 · 417 citations · Full text

Engineering, Bioengineering, Biomedical Engineering +17