Stimulation of humoral antibody formation by polyanions. IV. The effects of dextran sulfate on the kinetics of secondary immune response in mice

Abstract

Abstract Dextran sulfate enhances secondary immune response as well as primary immune response in mice primed and challenged with suboptimal doses of sheep red blood cells. Enhancement of primary response by dextran sulfate did not diminish secondary responses towards suboptimal antigen dose. However, in mice primed and challenged with an optimal antigen dose and injected at the time of priming with dextran sulfate, immunological memory seems to be increased. In primary as well as in secondary response the number of both 19 S and 7 S PFC were increased.