Publication | Closed Access
The Natural Lewis<sup>X</sup>‐Bearing Lipids Promote Membrane Adhesion: Influence of Ceramide on Carbohydrate–Carbohydrate Recognition
45
Citations
27
References
2005
Year
Proteinlipid InteractionEngineeringGlycobiologyAnalytical UltracentrifugationTight VesiclesBiophysicsLex=lewisx DeterminantBiochemistryCarbohydrate–carbohydrate RecognitionLipid ScienceMembrane BiologyMembrane SystemLipidsLex–lex RecognitionBiomolecular ScienceMembrane BiophysicsVesicle BiologyLipid ChemistryMedicine
Tight vesicles: Two glycosphingolipids, CerLLeX (see picture) and CerLLea (Cer=ceramide, L=lactose, LeX=LewisX determinant, Lea=Lewis a determinant) are used to study the Ca2+-mediated specific adhesion of natural LeX-bearing molecules inserted in fluid bilayer membranes. Vesicle adhesion energy experiments show that LeX–LeX recognition is highly sensitive to molecular structure.
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