Immunotoxins: hybrid molecules of monoclonal antibodies and a toxin subunit specifically kill tumour cells

Antibody-directed cytotoxic agents: use of monoclonal antibody to direct the action of toxin A chains to colorectal carcinoma cells.

D. Gray Gilliland, Zenon Steplewski, R. John Collier et al. · Proceedings of the National Academy of Sciences · 1980 · 270 citations · Full text

Pharmacy, Immunology, Oncology +17

Anti-Thy 1.2 monoclonal antibody linked to ricin is a potent cell-type-specific toxin.

Richard J. Youle, David M. Neville · Proceedings of the National Academy of Sciences · 1980 · 192 citations · Full text

Pharmacy, Biochemistry, Immunology +17

Selective killing of normal or neoplastic B cells by antibodies coupled to the A chain of ricin.

K A Krolick, C. L. Villemez, Peter C. Isakson et al. · Proceedings of the National Academy of Sciences · 1980 · 167 citations · Full text

Pharmacy, Immunology, Oncology +13

Toxicity of diphtheria toxin for lymphoblastoid cells is increased by conjugation to antilymphocytic globulin

P E Thorpe, W. C. J. Ross, A.J. Cumber et al. · Nature · 1978 · 86 citations

Pharmacy, Immunology, Toxicology +9

High specific cytotoxicity of antibody-toxin hybrid molecules (immunotoxins) for target cells

F. K. Jansen, H. Blythman, Dominique Carrière et al. · Immunology Letters · 1980 · 59 citations

Life Sciences, Immunology, Toxicology +10