IL-17 inhibits osteoblast differentiation and bone regeneration in rat

IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis

Shigeru Kotake, Nobuyuki Udagawa, Naoyuki Takahashi et al. · Journal of Clinical Investigation · 1999 · 1.7K citations · Full text

Sclerostin, Immunology, Osteoporosis +19

Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction

Kojiro Sato, Ayako Suematsu, Kazuo Okamoto et al. · The Journal of Experimental Medicine · 2006 · 1.5K citations · Full text

T-regulatory Cell, Immunology, T Cells +21

The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone loss

Mehmet A. Eskan, Ravi Jotwani, Toshiharu Abe et al. · Nature Immunology · 2012 · 410 citations

Inflammation, Cytokine, Autoimmune Disease +9

Blocking of Interleukin-17 during Reactivation of Experimental Arthritis Prevents Joint Inflammation and Bone Erosion by Decreasing RANKL and Interleukin-1

Marije I. Koenders, Erik Lubberts, Birgitte Oppers‐Walgreen et al. · American Journal Of Pathology · 2005 · 305 citations · Full text

Inflammation, Rheumatology, Cytokine +11

IL-17 stimulates the proliferation and differentiation of human mesenchymal stem cells: implications for bone remodeling

Hao Huang, Hyung Joon Kim, E-J Chang et al. · Cell Death and Differentiation · 2009 · 270 citations · Full text

Regenerative Medicine, Developmental Biology, Bone Morphogenic Protein +11