A Phase I, Dose-escalation Trial Evaluating the Safety and Efficacy of Emulsified Isoflurane in Healthy Human Volunteers

Abstract

EI is safe for intravenous injection in human volunteers in the dose range of 0.3 to 64.6 mg/kg. At doses of 22.6 mg/kg or higher, EI produced rapid onset of unconsciousness in all volunteers followed by fast, predictable, and complete recovery.