Aging negatively skews macrophage TLR2- and TLR4-mediated pro-inflammatory responses without affecting the IL-2-stimulated pathway

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

John C. Lee, Jeffrey T. Laydon, Peter McDonnell et al. · Nature · 1994 · 3.3K citations

Life Sciences, Immunology, Molecular Biology +14

Activation of interleukin-6 gene expression through the NF-kappa B transcription factor.

Towia A. Libermann, David Baltimore · Molecular and Cellular Biology · 1990 · 1.4K citations

Life Sciences, Cell Biology, Molecular Biology +16

Regulation of tumor necrosis factor alpha transcription in macrophages: involvement of four kappa B-like motifs and of constitutive and inducible forms of NF-kappa B.

Martine A. Collart, Patrick A. Baeuerle, P Vassalli · Molecular and Cellular Biology · 1990 · 888 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +16

Cutting Edge: Impaired Toll-Like Receptor Expression and Function in Aging

Mary Renshaw, Julie Rockwell, Carrie Engleman et al. · The Journal of Immunology · 2002 · 625 citations · Full text

Life Sciences, Immunology, Microbiology +17

Jun N-Terminal Kinase/Stress-Activated Protein Kinase (JNK/SAPK) Is Required for Lipopolysaccharide Stimulation of Tumor Necrosis Factor Alpha (TNF-α) Translation: Glucocorticoids Inhibit TNF-α Translation by Blocking JNK/SAPK

Jennifer L. Swantek, Melanie H. Cobb, T D Geppert · Molecular and Cellular Biology · 1997 · 490 citations · Full text

Life Sciences, Immunology, Molecular Biology +17