New England Journal of Medicine · 2012 · 70 citations · 7 references
Life SciencesBiotechnologyNeurological SurgeryCell TherapyRegenerative MedicineStem Cell BiologyCell-based TherapiesEmbryonic Stem CellsNeural Stem Cell BiologySpinal Cord InjurySpinal Cord PathologySpinal TraumaAcute Spinal Cord Injury CareSpinal Cord Injury RepairSpinal Cord RegenerationSpinal Cord RepairSpinal Injuries
For the past couple of decades, clinicians have watched the stem-cell field with a mixture of anticipation and skepticism. No group of patients has been more expectant than those with spinal cord injuries. Therapies for spinal cord injury have been promised almost since the dawning of the stem-cell field. The recent launch — and abrupt termination — of a phase 1 clinical trial for acute spinal cord injury by the biotechnology company Geron whetted the appetite, and then fueled the frustration, of these patients.A recent study by Sakai et al.1 is one of a series in this field. It . . .
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Kiyoshi Sakai, Akihito Yamamoto, Kohki Matsubara et al. · Journal of Clinical Investigation · 2011 · 529 citations · Full text
D. Eugene Redmond, Kimberly B. Bjugstad, Yang D. Teng et al. · Proceedings of the National Academy of Sciences · 2007 · 344 citations · Full text