Association of Bone Metabolism Regulatory Factor Gene Polymorphisms With Susceptibility to Ossification of the Posterior Longitudinal Ligament of the Spine and Its Severity

Abstract

The contribution of genetic backgrounds is likely to be stronger in women than in men with ossification of the posterior longitudinal ligament of the spine. Estrogen receptor polymorphism was associated with both initiation and promotion of the disorder, but interleukin-1beta polymorphism was associated only with its initiation in women.