Concepedia

Etomidate reduces glutamate uptake in rat cultured glial cells: involvement of PKA

M. Rath, Karl J. Föhr, Henry U. Weigt, Annika Gauss, Jürgen Engele, Michael Georgieff, Sarah Köster, Oliver Adolph

British Journal of Pharmacology · 2008 · 19 citations · 45 references

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Abstract

Inhibition of glutamate uptake by etomidate at clinically relevant concentrations may affect glutamatergic neurotransmission by increasing the glutamate concentration in the synaptic cleft and may compromise patients suffering from acute or chronic neurological disorders such as CNS trauma or epilepsy.

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