Acute elevation of free fatty acid levels leads to hepatic insulin resistance in obese subjects

Glucose clamp technique: a method for quantifying insulin secretion and resistance.

R. A. DeFronzo, J. D. Tobin, R Andres · American Journal of Physiology-Endocrinology and Metabolism · 1979 · 7.5K citations

Medicine, Biochemistry, Endocrinology +17

Classification and Diagnosis of Diabetes Mellitus and Other Categories of Glucose Intolerance

Diabetes · 1979 · 4.9K citations

Medicine, Endocrinology, Internal Medicine +7

INFLUENCES OF GLUCOSE LOADING AND OF INJECTED INSULIN ON HEPATIC GLUCOSE OUTPUT*

Robert D. Steele · Annals of the New York Academy of Sciences · 1959 · 1.7K citations

Medicine, Biochemistry, Endocrinology +10

Effect of fatty acids on glucose production and utilization in man.

Eleuterio Ferrannini, Edward J. Barrett, Sergio Bevilacqua et al. · Journal of Clinical Investigation · 1983 · 1.1K citations · Full text

Life Sciences, Endocrinology, Physiology +17

Regulation of glucose uptake by muscle. 8. Effects of fatty acids, ketone bodies and pyruvate, and of alloxan-diabetes and starvation, on the uptake and metabolic fate of glucose in rat heart and diaphragm muscles

Randle Pj, E. A. Newsholme, P. B. Garland · Biochemical Journal · 1964 · 736 citations · Full text

Life Sciences, Biochemistry, Physiology +17