A loss-of-function mutation of c-kit results in depletion of mast cells and interstitial cells of Cajal, while its gain-of-function mutation results in their oncogenesis

Gain-of-Function Mutations of c- <i>kit</i> in Human Gastrointestinal Stromal Tumors

Seiichi Hirota, Koji Isozaki, Y Moriyama et al. · Science · 1998 · 4.5K citations

Medicine, Genetics, Oncology +17

Human proto‐oncogene c‐kit: a new cell surface receptor tyrosine kinase for an unidentified ligand.

Yosef Yarden, Wun-Jing Kuang, Teresa L. Yang‐Feng et al. · The EMBO Journal · 1987 · 1.6K citations · Full text

Life Sciences, Molecular Biology, Oncology +13

Stem cell factor is encoded at the SI locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor

Krisztina M. Zsebo, David A. Williams, E N Geissler et al. · Cell · 1990 · 1.4K citations

Life Sciences, Cell Biology, Genetics +14

W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity

Jan D. Hulzinga, Lars Thuneberg, Michael Klüppel et al. · Nature · 1995 · 1.4K citations

Life Sciences, Genetics, Molecular Biology +10

The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus

Benoı̂t Chabot, Dennis A. Stephenson, Verne M. Chapman et al. · Nature · 1988 · 1.4K citations

Life Sciences, Genetics, Molecular Biology +12