Concepedia

Sphingolipids and the sphingosine kinase inhibitor, SKI II, induce BCL‐2‐independent apoptosis in human prostatic adenocarcinoma cells

Michele LeRoux, Edmond J. Auzenne, Randall Evans, Numsen Hail, William H. Spohn, Sukhen C. Ghosh, D. Farquhar, Timothy McDonnell, Jim Klostergaard

The Prostate · 2007 · 40 citations · 63 references

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Open access

Abstract

Thus, in contrast to the inhibitory effects of BCL-2 on apoptosis induced by various agents in tumor cells, SKI II and selected pro-apoptotic SLs appear atypical in their independence from such inhibition, and may have merits as new candidates for treatment of AI PC.

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