Nuclear–cytoplasmic shuttling of BARD1 contributes to its proapoptotic activity and is regulated by dimerization with BRCA1

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RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

Kevin L. Lorick, Jane P. Jensen, Shengyun Fang et al. · Proceedings of the National Academy of Sciences · 1999 · 1.2K citations

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A DNA vector-based RNAi technology to suppress gene expression in mammalian cells

Guangchao Sui, Christina Soohoo, El Bachir Affar et al. · Proceedings of the National Academy of Sciences · 2002 · 1.1K citations · Full text

Life Sciences, Genetics, Molecular Biology +11

Dynamic Changes of BRCA1 Subnuclear Location and Phosphorylation State Are Initiated by DNA Damage

Ralph Scully, Junjie Chen, Robert Ochs et al. · Cell · 1997 · 909 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Identification of a RING protein that can interact in vivo with the BRCA1 gene product

Leeju C. Wu, Zhuo Wei Wang, Julia Tsou Tsan et al. · Nature Genetics · 1996 · 752 citations

Life Sciences, Genetics, Molecular Biology +11