Development of obesity in transgenic mice after genetic ablation of brown adipose tissue

A role for brown adipose tissue in diet-induced thermogenesis

Nancy J. Rothwell, Michael J. Stock · Nature · 1979 · 1.6K citations

Life Sciences, Biochemistry, Physiology +14

Tissue distribution of cold-induced thermogenesis in conscious warm- or cold-acclimated rats reevaluated from changes in tissue blood flow: The dominant role of brown adipose tissue in the replacement of shivering by nonshivering thermogenesis

David O. Foster, M. Lorraine Frydman · Canadian Journal of Physiology and Pharmacology · 1979 · 519 citations

Life Sciences, Anatomy, Physiology +17

Cell lineage ablation in transgenic mice by cell-specific expression of a toxin gene

Richard D. Palmiter, Richard R. Behringer, Carol J. Quaife et al. · Cell · 1987 · 479 citations

Life Sciences, Cell Biology, Molecular Biology +15

Mitochondrial uncoupling protein from mouse brown fat. Molecular cloning, genetic mapping, and mRNA expression.

Anders Jacobsson, U Stadler, Michael Glotzer et al. · Journal of Biological Chemistry · 1985 · 301 citations · Full text

Life Sciences, Genetics, Molecular Biology +15

Disodium (R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent .beta.-adrenergic agonist virtually specific for .beta.3 receptors. A promising antidiabetic and antiobesity agent

Jonathan D. Bloom, Minu Dutia, Bernard D. Johnson et al. · Journal of Medicinal Chemistry · 1992 · 297 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +8