Common Structure of Soluble Amyloid Oligomers Implies Common Mechanism of Pathogenesis

Rakez Kayed, Elizabeth Head, Jennifer L. Thompson, +4

Science

Soluble Amyloid OligomersAlzheimer's DiseaseBiochemistryProtein AssemblyProtein Folding +10

Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

Dale Schenk, Robin Barbour, Whitney Dunn, +22

Nature

Neurodegenerative DiseasesAlzheimer's DiseaseImmunologyDegenerative PathologyProtein Misfolding +5

Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

Frédérique Bard, Catherine Cannon, Robin Barbour, +20

Nature Medicine

Amyloid β-Peptide EnterNeurodegenerative DiseasesAlzheimer's DiseaseMedicineImmunology +11

Natural oligomers of the amyloid-β protein specifically disrupt cognitive function

James Cleary, Dominic M. Walsh, J. Hofmeister, +4

Nature Neuroscience

Neurodegenerative DiseasesMolecular NeuroscienceMolecular BiologyNatural OligomersNeurochemical Biomarkers +3

Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

Dave Morgan, David M. Diamond, Paul E. Gottschall, +12

Nature

VaccinationNeurodegenerative DiseasesAlzheimer's DiseaseMedicineMemory Loss +12

Subacute meningoencephalitis in a subset of patients with AD after Aβ42 immunization

J. M. Orgogozo, S. Gilman, Jean‐François Dartigues, +11

Neurology

Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model

Jean‐Cosme Dodart, Kelly R. Bales, Kimberley S. Gannon, +8

Nature Neuroscience

ImmunologyImmunodominanceSocial SciencesMemory DeficitsAlzheimer's Disease +17

Neuropathology and Pathogenesis of Encephalitis following Amyloid β Immunization in Alzheimer's Disease

Isidró Ferrer, Merçé Boada, María Luisa Sánchez Guerra, +2

Brain Pathology

ImmunologyAmyloid BurdenTransgenic Pdapp MiceNeuroinflammationVascular Amyloid +18

Amyloid β protein immunotherapy neutralizes Aβ oligomers that disrupt synaptic plasticity in vivo

Igor Klyubin, Dominic M. Walsh, Cynthia A. Lemere, +8

Nature Medicine

Synaptic PlasticityNeurodegenerative DiseasesAlzheimer's DiseaseSynaptic NeuroscienceSynaptic Transmission +9

Passive immunotherapy against Abeta in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage.

Donna M. Wilcock, Amyn M. Rojiani, Arnon Rosenthal, +4

Journal of Neuroinflammation