Concepedia

Genetic Variants in IL-23R and ATG16L1 Independently Predispose to Increased Susceptibility to Crohn's Disease in a Canadian Population

William G. Newman, Qing Zhang, Xiangdong Liu, Christopher I. Amos, Katherine Siminovitch

Journal of Clinical Gastroenterology · 2009 · 39 citations · 28 references

DOI

Abstract

We confirm the association of CD with variants in the IL-23R and ATG16L1 genes and the more modest association of the IL-23R R381Q variant with UC. Our results also suggest that these variants act independently of one another to influence risk and pathogenesis of IBD.

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