Induction of Drug Metabolism Enzymes and MDR1 Using a Novel Human Hepatocyte Cell Line

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.

J�rgen Lehmann, David D. McKee, M. A. Watson et al. · Journal of Clinical Investigation · 1998 · 1.6K citations · Full text

Genetics, Cyp3a4 Gene, Mouse Pxr Reveals +18

Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P-450

M.D. Burke, S. Thompson, Clifford R. Elcombe et al. · Biochemical Pharmacology · 1985 · 1.3K citations

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Identification of a human nuclear receptor defines a new signaling pathway for <i>CYP</i> <i>3</i> A induction

Göran Bertilsson, Jessica Heidrich, Kristian Svensson et al. · Proceedings of the National Academy of Sciences · 1998 · 868 citations · Full text

Nuclear Receptor Response Elements Mediate Induction of Intestinal MDR1 by Rifampin

Anke Geick, Michel Eichelbaum, Oliver Burk · Journal of Biological Chemistry · 2001 · 840 citations · Full text

Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells.

Erin G. Schuetz, W T Beck, John D. Schuetz · Molecular Pharmacology · 1996 · 496 citations