Fluorinated benzamide neuroleptics. 1. Radiosynthesis of (S)‐N‐[(1‐ethyl‐2‐pyrrolidinyl)methyl]‐5‐(2[F‐18]fluoroethyl)‐2‐methoxybenzamide: A potential fluorine‐18 labeled PET radiotracer for dopamine D2 receptors

Abstract

Abstract The synthesis of a tosylate precursor for the radiosynthesis of a potential PET radiotracer, (S)‐N‐[(1‐ethyl‐2‐pyrrolidinyl)methyl]‐5‐(2‐[ 18 F]fluoroethyl)‐2‐ methoxybenzamide is reported. Reaction of 18 F‐fluoride with the tosylate provides the radiolabeled product in 10–25% yield. Specific activity of the radiotracer varied between 600–800 Ci/mmol after purification of the product mixture by reverse phase HPLC.