An Enzymatic Domain for the Formation of Cyclic Ethers in Complex Polyketides

Abstract

Champion cyclist: In vitro studies on the pederin biosynthetic pathway identify pyran synthases (PS) as a new family of polyketide synthase domains that stereoselectively form diverse five- and six-membered ether rings by oxa-conjugate cyclization during carbon-chain elongation. These domains could be useful tools for chemoenzymatic synthesis. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.