A New Mechanism Preventing Proarrhythmia in Chronic Heart Failure: Rapid Phase-III Repolarization Explains the Low Proarrhythmic Potential of Amiodarone in Contrast to Sotalol in a Model of Pacing-Induced Heart Failure

Abstract

Chronic amiodarone results in a rapid phase-III-repolarization and does not increase dispersion of repolarization. These electrophysiological findings are present in healthy hearts and are preserved in heart failure. This contributes to the low proarrhythmic potential of amiodarone in heart failure.