Synthesis of a Stimulus‐Responsive Processing Device and Its Application to a Nucleocytoplasmic Shuttle Peptide

Abstract

Stimulus and response. Stimulus-responsive processing (peptide bond cleavage) devices were developed. The processing reaction was triggered by stimulus-induced removal of a PG, and the processing products were obtained in good purity. A photo-responsive processing device was successfully applied to develop a nucleocytoplasmic shuttle peptide. (F: fluorophore, NES: nuclear export signal. NLS: nuclear localization signal. PG: stimulus-responsive protective group) Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2268/2007/z700442_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.