1c:I[419806,["/_next/static/chunks/bb923814e1f4d2e9.js","/_next/static/chunks/dd3ee9f5b7716ca6.js","/_next/static/chunks/4204a0ae82542ca8.js","/_next/static/chunks/1270dead247da766.js","/_next/static/chunks/6e1aa89a642f40be.js","/_next/static/chunks/2d7aa753e81324a8.js","/_next/static/chunks/8ffd0b71567920d8.js","/_next/static/chunks/67ea6dfd21f16c5f.js","/_next/static/chunks/24eb4379f68013fd.js","/_next/static/chunks/b8cd775ffdf935bd.js","/_next/static/chunks/983103cd9eb7b428.js","/_next/static/chunks/263f2cdcb9aa2341.js","/_next/static/chunks/294b9525248c8e5f.js"],"default"] 1d:T463,Recurrent aphthous stomatitis (recurrent aphthae) is a disease of man characterized by painful, recurrent, single or multiple necrotizing ulcerations of mucosal tissues. The primary cause has not been established and there is no specific therapy. Several microbial agents have been incriminated, including herpes simplex and other viruses,Toxoplasma, the organisms which cause Vincent's angina, and other bacterial agents including the pleomorphic, transitional L-froms of an α-hemolytic streptococcus (Streptococcus sanguis) (see reviews for references^1-3). Recurrence may be precipitated by trauma, hormonal changes in women, physical or psychic stress, and chemical irritants. The disease has been associated with allergic and genetic factors. Moreover, recurrent aphthae is often erroneously confused with herpes simplex infection and it may have clinical and histological aspects in common with Behcet's, Stevens-Johnson, and Reiter's syndrome. No less than 20 different synonyms have been used to characterize this disease.^1-3 To the practicing physician, the combined problems of1e:T463,Recurrent aphthous stomatitis (recurrent aphthae) is a disease of man characterized by painful, recurrent, single or multiple necrotizing ulcerations of mucosal tissues. The primary cause has not been established and there is no specific therapy. Several microbial agents have been incriminated, including herpes simplex and other viruses,Toxoplasma, the organisms which cause Vincent's angina, and other bacterial agents including the pleomorphic, transitional L-froms of an α-hemolytic streptococcus (Streptococcus sanguis) (see reviews for references^1-3). Recurrence may be precipitated by trauma, hormonal changes in women, physical or psychic stress, and chemical irritants. The disease has been associated with allergic and genetic factors. Moreover, recurrent aphthae is often erroneously confused with herpes simplex infection and it may have clinical and histological aspects in common with Behcet's, Stevens-Johnson, and Reiter's syndrome. No less than 20 different synonyms have been used to characterize this disease.^1-3 To the practicing physician, the combined problems of

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