ChemBioChem · 2007 · 249 citations · 16 references
MedicineMolecular BiologyOncologyMolecular DiagnosticsMolecular OncologyPrecision OncologyCancer BiotechnologyCancer Molecular DiagnosticsAptamer ChemistryAptamer DesignAptamer EngineeringAptamersNucleic Acid Aptamer SelectionSingle-stranded Dna Stability
To cut a long story short. Single-stranded DNA aptamers that can recognize cancer cells specifically were optimized and modified. The modifications gave rise to aptamers that were much smaller in size (see scheme) and more stable in fetal bovine serum. This stability makes it possible to apply aptamers to in vivo applications, such as diagnosis and therapy.
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In vitro selection of RNA molecules that bind specific ligands
Andrew D. Ellington, Jack W. Szostak · Nature · 1990 · 9.7K citations