Relation of cellular drug resistance to long-term clinical outcome in childhood acute lymphoblastic leukaemia

Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples

Richard Peto, M. C. Pike, P. Armitage et al. · British Journal of Cancer · 1977 · 8.4K citations · Full text

Public Health, Biostatistics, Clinical Medicine +13

Thiopurine pharmacogenetics in leukemia: Correlation of erythrocyte thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations

Lynne Lennard, Jon A. Van Loon, John Lilleyman et al. · Clinical Pharmacology & Therapeutics · 1987 · 348 citations

Medicine, Hematology, Pharmacology +13

Appraisal of the MTT assay as a rapid test of chemosensitivity in acute myeloid leukaemia

JM Sargent, CG Taylor · British Journal of Cancer · 1989 · 291 citations · Full text

Medicine, Hematology, Oncology +10

Variable mercaptopurine metabolism and treatment outcome in childhood lymphoblastic leukemia.

Lynne Lennard, J S Lilleyman · Journal of Clinical Oncology · 1989 · 248 citations

Medicine, Hematology, Oncology +15

In vitro drug sensitivity of cells from children with leukemia using the MTT assay with improved culture conditions

Rob Pieters, AH Loonen, DR Huismans et al. · Blood · 1990 · 231 citations · Full text

Medicine, Oncology, Pharmacology +8