Pd(<scp>ii</scp>)-catalyzed C–H arylation of aryl and benzyl Weinreb amides

Abstract

The first example of palladium-catalyzed ortho-C-H arylation of aryl and benzyl Weinreb amides was developed, in which HOTf was used as a key promoter. This method exhibits good functional group tolerance, a broad substrate scope of both Weinreb amides and aryl iodides, high mono-selectivity and mild reaction conditions.