Post-irradiation hypoxic incubation of X-irradiated MOLT-4 cells reduces apoptotic cell death by changing the intracellular redox state and modulating SAPK/JNK pathways

Dominant-Negative c-Jun Promotes Neuronal Survival by Reducing BIM Expression and Inhibiting Mitochondrial Cytochrome c Release

Jonathan R. Whitfield, Stephen J. Neame, Luc Paquet et al. · Neuron · 2001 · 563 citations · Full text

Molecular Neuroscience, Mitochondrial Function, Physiology +11

Translocation of SAPK/JNK to Mitochondria and Interaction with Bcl-xL in Response to DNA Damage

Surender Kharbanda, Satya Saxena, Kiyotsugu Yoshida et al. · Journal of Biological Chemistry · 2000 · 428 citations · Full text

Hypoxia-Mediated Down-Regulation of Bid and Bax in Tumors Occurs via Hypoxia-Inducible Factor 1-Dependent and -Independent Mechanisms and Contributes to Drug Resistance

Janine T. Erler, Christopher Cawthorne, Kaye J. Williams et al. · Molecular and Cellular Biology · 2004 · 386 citations · Full text

Solid Tumors, Apoptosis, Cell Death +18

The hypoxia-inducible factor-1α is a negative factor for tumor therapy

Annika Unruh, Anke Ressel, Hamid G Mohamed et al. · Oncogene · 2003 · 333 citations

Tumor Biology, Oncology, Tumor Therapy +7

JNK Phosphorylation and Activation of BAD Couples the Stress-activated Signaling Pathway to the Cell Death Machinery

Nicole Donovan, Esther B. E. Becker, Yoshiyuki Konishi et al. · Journal of Biological Chemistry · 2002 · 249 citations · Full text