A Linear Solvation Free Energy Relationship Analysis of Solubilization in Mixed Cationic−Nonionic Micelles

Abstract

Incorporation coefficients for binding of 29 nonionic solutes to cationic/nonionic mixed micelles (1:1 molar ratio of hexadecyltrimethylammonium bromide (CTAB)/ polyoxyethylene[23]dodecyl ether (Brij 35)) were employed to establish a linear solvation free energy relationship (LSER) based on five solute parameters. Comparison of this LSER with those for solute incorporation into micelles of the pure, unmixed detergents indicates that hydrogen-bonding interactions are the predominant contributors to the nonidealities of solubilization in the mixed micelle.