Cell Death by SecTRAPs: Thioredoxin Reductase as a Prooxidant Killer of Cells

Abstract

We conclude that formation of SecTRAPs could contribute to the cytotoxicity seen upon exposure of cells to electrophilic agents targeting TrxR. SecTRAPs are prooxidant killers of cells, triggering mechanisms beyond those of a mere loss of thioredoxin reductase activity.