Orthogonal Synthesis of Isoindole and Isoquinoline Derivatives from Organic Azides

Abstract

Alpha-azido carbonyl compounds bearing a 2-alkenylaryl moiety at the alpha-position are found to be promising precursors for synthesis of isoindole and isoquinoline derivatives via 1,3-dipolar cycloaddition of azides onto alkenes and 6pi-electrocyclization of N-H imine intermediates, respectively.