Pharmacology of neuropeptide S in mice: therapeutic relevance to anxiety disorders

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

Life Sciences, Biochemistry, Chemical Kinetics +14

Validation of open : closed arm entries in an elevated plus-maze as a measure of anxiety in the rat

Sharon Pellow, Philippe Chopin, Sandra E. File et al. · Journal of Neuroscience Methods · 1985 · 5.8K citations

Social Sciences, Behavioral Sciences, Psychology +9

The tail suspension test: A new method for screening antidepressants in mice

Lucien Stéru, R Chermat, Bernard Thierry et al. · Psychopharmacology · 1985 · 3.5K citations

Medicine, Pharmacology, Behavioral Pharmacology +11

Selective antagonists of benzodiazepines

Walter Hunkeler, H. Möhler, L. Pieri et al. · Nature · 1981 · 1.2K citations

Medicine, Pharmacology, Pharmacotherapy +9

Behavioural and pharmacological characterisation of the elevated “zero-maze” as an animal model of anxiety

Jon K. Shepherd, Savraj Grewal, Allan Fletcher et al. · Psychopharmacology · 1994 · 742 citations

Medicine, Neuroscience, Pharmacology +14