Concepedia

PTEN catalysis of phospholipid dephosphorylation reaction follows a two-step mechanism in which the conserved aspartate-92 does not function as the general acid — Mechanistic analysis of a familial Cowden disease-associated PTEN mutation

Yi Xiao, Joel Yeong Chit Chia, Joanna E. Gajewski, Daisy Lio, Terrence D. Mulhern, Hong‐Jian Zhu, Harshal Nandurkar, Heung‐Chin Cheng

Cellular Signalling · 2007 · 30 citations · 28 references

DOI

Concepts

References

28

<i>PTEN</i> , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

Jing Li, Clifford Yen, Danny Liaw et al. · Science · 1997 · 4.8K citations

The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate

Tomohiko Maehama, Jack E. Dixon · Journal of Biological Chemistry · 1998 · 3.1K citations · Full text

Inhibition of Cell Migration, Spreading, and Focal Adhesions by Tumor Suppressor PTEN

Masahito Tamura, Jianguo Gu, Kazue Matsumoto et al. · Science · 1998 · 1.2K citations

, , +17

Crystal Structure of the PTEN Tumor Suppressor

Jie‐Oh Lee, Haijuan Yang, Maria-Magdalena Georgescu et al. · Cell · 1999 · 1K citations · Full text

, , +5

Extending the Applicability of the Nonlinear Poisson−Boltzmann Equation:  Multiple Dielectric Constants and Multivalent Ions

Walter Rocchia, Emil Alexov, Barry Honig · The Journal of Physical Chemistry B · 2001 · 828 citations

, , +20