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PTEN catalysis of phospholipid dephosphorylation reaction follows a two-step mechanism in which the conserved aspartate-92 does not function as the general acid — Mechanistic analysis of a familial Cowden disease-associated PTEN mutation

Phospholipid Dephosphorylation ReactionSignal TransductionBiochemistryNatural SciencesInherited Metabolic DiseaseBiochemical GeneticsMolecular BiologyTwo-step MechanismPten CatalysisMedicineProtein PhosphorylationMolecular Medicine