Characterization of an Obese Syndrome in the Pig

Abstract

SummaryMetabolic abnormalities associated with obesity were studied with two strains of pigs possessing varying propensities for lipid and protein deposition. The lean strain has a subcutaneous fat thickness of 2.8 cm and the obese strain, 8.0 cm. Adipose tissue enzymes associated with lipogenesis were elevated severalfold in the obese pig. The same enzymes in the liver were not altered. Gluconeogenic enzymes were elevated in the obese pig indicating a shift in the metabolism of amino acids. Enzymatic response to fasting and refeeding appears to be more dynamic in the lean type pig.