Radiosensitization by SAHA in Experimental Colorectal Carcinoma Models—In Vivo Effects and Relevance of Histone Acetylation Status

Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses the growth of prostate cancer cells in vitro and in vivo.

Lisa M. Butler, David B. Agus, Howard I. Scher et al. · PubMed · 2000 · 617 citations

Chemoprevention Strategy, Prostate Cancer Cells, Cancer Biology +18

Cell-cycle arrest versus cell death in cancer therapy

Todd Waldman, Yonggang Zhang, Larry E. Dillehay et al. · Nature Medicine · 1997 · 386 citations

Cancer Therapy, Medicine, Metronomic Chemotherapy +5

Modulation of radiation response by histone deacetylase inhibition

Prakash Chinnaiyan, Geetha D. Vallabhaneni, Eric A. Armstrong et al. · International Journal of Radiation Oncology*Biology*Physics · 2005 · 242 citations

Histone Modifications, Chromatin, Chromatin Remodeling +7

Vorinostat, a histone deacetylase inhibitor, enhances the response of human tumor cells to ionizing radiation through prolongation of γ-H2AX foci

Anupama Munshi, Toshimitsu Tanaka, Marvette L. Hobbs et al. · Molecular Cancer Therapeutics · 2006 · 218 citations

Histone Deacetylase Inhibitor, Radiation Effect, Hybrid Polar Compounds +22

Enhanced Radiation-Induced Cell Killing and Prolongation of γH2AX Foci Expression by the Histone Deacetylase Inhibitor MS-275

Kevin Camphausen, William Burgan, Michael Cerra et al. · Cancer Research · 2004 · 211 citations