Convenient Preparation of 2-Deoxy-3,5-di-O-<i>p</i>-toluoyl-α-D-<i>erythro</i>-pentofuranosyl Chloride

Abstract

Abstract By using acetyl chloride as HCl generator, the procedure for the Hoffer preparation of the α-chloro sugar 4a was significantly improved. The α-configuration of the chloro atom was confirmed by using NOE measurement. Sequential transformation of 4a to the β-anomer and to the furfuryl derivative 6 was studied.