Science · 1975 · 519 citations · 32 references
Life SciencesGeneticsMolecular BiologyGene RegulationNucleic Acid BiochemistryTranscriptional RegulationGene Expression RegulationPromoter RecognitionPromoter RegulationRna Polymerase RegulationRna TranscriptionTranscriptional ControlActive Site RecognitionGene Promoter RegulationLac Operon OrganizationPromoter ControlPromoter Sequence MotifsPromoter-promoter InteractionsPromotersTranscriptional Regulation By Rna Polymerase
The nucleotide sequence of the lac promoter-operator region has been determined. The 122 base pairs comprising this region include the recognition sites for RNA polymerase, the positive regulatory protein, CAP, and the negative regulatory protein, the repressor. Identification of mutant variants of the sequence combined with the in vitro biochemical studies of others has allowed us to tentatively identify the recognition site for each of these proteins, and to suggest how CAP might act at a distance to affect the interaction of RNA polymerase with the promoter.
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Mechanism of the Antitumour Effect of Interferon in Mice
Ion Gresser, Chantal Maury, Danièle Brouty‐Boyé · Nature · 1972 · 314 citations