Effects of Acoustic Parameters and Ultrasound Contrast Agent Dose on Focused-Ultrasound Induced Blood-Brain Barrier Disruption

Noninvasive MR Imaging–guided Focal Opening of the Blood-Brain Barrier in Rabbits

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Medicine, Biomedical Engineering, Radiology +17

Convection-enhanced delivery of macromolecules in the brain.

R. Hunt Bobo, Douglas W. Laske, Aytaç Akbaşak et al. · Proceedings of the National Academy of Sciences · 1994 · 1.4K citations

Pharmacy, Neuroscience, Pharmaceutics +16

Local and reversible blood–brain barrier disruption by noninvasive focused ultrasound at frequencies suitable for trans-skull sonications

Kullervo Hynynen, Nathan McDannold, Nickolai Sheikov et al. · NeuroImage · 2004 · 686 citations

Engineering, Biomedical Engineering, Neuroscience +12

Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood–brain barrier disruption

Manabu Kinoshita, Nathan McDannold, Ferenc A. Jólesz et al. · Proceedings of the National Academy of Sciences · 2006 · 649 citations · Full text

Pharmacy, Pharmaceutics, Pharmacology +17

Cellular mechanisms of the blood-brain barrier opening induced by ultrasound in presence of microbubbles

Nickolai Sheikov, Nathan McDannold, Natalia Vykhodtseva et al. · Ultrasound in Medicine & Biology · 2004 · 620 citations

Medicine, Biophysics, Neuroscience +14