The immediate precursor of the nitrogen-containing ring of rapamycin is free pipecolic acid

FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics.

Toru Kino, Hiroshi Hatanaka, MICHISANE HASHIMOTO et al. · The Journal of Antibiotics · 1987 · 1.2K citations · Full text

Medicine, Biochemistry, Pharmacology +10

Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization.

Suren N. Sehgal, Hinton J. Baker, Claude Vézina · The Journal of Antibiotics · 1975 · 958 citations · Full text

Medicine, Medicinal Chemistry, Microbiology +8

Inhibition of the immune response by rapamycin, a new antifungal antibiotic

R. R. Martel, J. Klicius, S. Galet · Canadian Journal of Physiology and Pharmacology · 1977 · 453 citations

Medicine, Immunology, Pharmacology +11

Activity of rapamycin (AY-22,989) against transplanted tumors.

C. P. Eng, Suren N. Sehgal, Claude Vézina · The Journal of Antibiotics · 1984 · 341 citations · Full text

Medicine, Oncology, Pharmacology +7

ENZYMATIC SYNTHESIS OF l-PIPECOLIC ACID AND l-PROLINE

Alton Meister, A.N. Radhakrishnan, Sarah Buckley · Journal of Biological Chemistry · 1957 · 156 citations · Full text

Life Sciences, Biochemistry, Biotechnology +6