Concepedia

Role of P-Glycoprotein Inhibition for Drug Interactions

Sonja Eberl, Bertold Renner, Antje Neubert, Mareike Reisig, Iouri Bachmakov, Jörg König, Frank Dörje, Thomas E. Mürdter, Andreas Ackermann, Harald Dormann,

Clinical Pharmacokinetics · 2007 · 114 citations · 30 references

DOI

Concepts

References

30

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

R. L. Juliano, Victor Ling · Biochimica et Biophysica Acta (BBA) - Biomembranes · 1976 · 3.3K citations

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The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors.

Richard B. Kim, Martin F. Fromm, Christoph Wandel et al. · Journal of Clinical Investigation · 1998 · 1.1K citations · Full text

, , +17

The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin

Bernd Greiner, Michel Eichelbaum, Péter Fritz et al. · Journal of Clinical Investigation · 1999 · 920 citations · Full text

, , +9

Association of Serum Digoxin Concentration and Outcomes in Patients With Heart Failure

Saif S. Rathore, Jeptha P. Curtis, Yongfei Wang et al. · JAMA · 2003 · 769 citations

, , +11

Interrelationship Between Substrates and Inhibitors of Human CYP3A and P-Glycoprotein

Richard B. Kirn, Christoph Wandel, Brenda F. Leake et al. · Pharmaceutical Research · 1999 · 460 citations

, , +10