Role of P-Glycoprotein Inhibition for Drug Interactions

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

R. L. Juliano, Victor Ling · Biochimica et Biophysica Acta (BBA) - Biomembranes · 1976 · 3.3K citations

Drug Targeting, Glycosylation, Medicine +12

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors.

Richard B. Kim, Martin F. Fromm, Christoph Wandel et al. · Journal of Clinical Investigation · 1998 · 1.1K citations · Full text

Oral Bioavailability, Immunology, Pharmacotherapy +17

The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin

Bernd Greiner, Michel Eichelbaum, Péter Fritz et al. · Journal of Clinical Investigation · 1999 · 916 citations · Full text

Association of Serum Digoxin Concentration and Outcomes in Patients With Heart Failure

Saif S. Rathore, Jeptha P. Curtis, Yongfei Wang et al. · JAMA · 2003 · 757 citations

Interrelationship Between Substrates and Inhibitors of Human CYP3A and P-Glycoprotein

Richard B. Kirn, Christoph Wandel, Brenda F. Leake et al. · Pharmaceutical Research · 1999 · 459 citations