Expression of p-glycoprotein is associated with that of multidrug resistance protein 1 (MRP1) in the vestibular labyrinth and endolymphatic sac of the guinea pig

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

Alfred H. Schinkel, Jasper Smit, Olaf van Tellingen et al. · Cell · 1994 · 2.3K citations

Medicine, Pharmacokinetics, Pharmacology +14

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

Carlos Cordon‐Cardo, James P. O’Brien, D Casals et al. · Proceedings of the National Academy of Sciences · 1989 · 1.7K citations · Full text

Medicine, Oncology, Pharmacology +16

Choroid plexus epithelial expression of <i>MDR</i> <i>1</i> P glycoprotein and multidrug resistance-associated protein contribute to the blood–cerebrospinal-fluid drug-permeability barrier

V. Venkat Rao, Julie L. Dahlheimer, Mark E. Bardgett et al. · Proceedings of the National Academy of Sciences · 1999 · 529 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +17

Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier

Jan Wijnholds, Elizabeth C. M. de Lange, George L. Scheffer et al. · Journal of Clinical Investigation · 2000 · 359 citations · Full text

Medicine, Oncology, Pharmacology +15

Nature of Blood-Labyrinth Barrier in Experimental Conditions

Steven K. Juhn, Leonard P. Rybak, S. Prado · Annals of Otology Rhinology & Laryngology · 1981 · 127 citations

Medicine, Pharmacology, Physiology +14